Synthesis of ?2-microglobulin-free, disulphide-linked HLA-G5 homodimers in human placental villous cytotrophoblast cells
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چکیده
منابع مشابه
2-Arachidonoylglycerol impairs human cytotrophoblast cells syncytialization: influence of endocannabinoid signalling in placental development.
A balanced cytotrophoblast cell turnover is crucial for placental development and anomalies in this process associated with gestational diseases. The endocannabinoid system (ECS) has emerged as a new player in several biological processes. However, its influence during placental development is still unknown. We report here the expression of the endocannabinoid 2-arachidonoylglycerol (2-AG) main...
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The aim of this study was to determine whether extracellular ATP ([ATP](o)) stimulated a Ca(2+)-activated K(+) efflux in trophoblast cells that was dependent on extracellular Ca(2+) ([Ca(2+)](o)). Cytotrophoblast cells, isolated from human placenta, were examined following 18 h (relatively undifferentiated) and 66 h (multinucleate cells) of culture. Potassium efflux was measured using (86)Rb as...
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The syncytiotrophoblast (ST) is one of the major components of the human placenta, as it is involved in feto-maternal exchanges and the secretion of pregnancy-specific hormones. The aim of this study was to elucidate the formation and function of the ST in trisomy 21 (Down's syndrome). We first used the in vitro model of cytotrophoblast differentiation into ST. Cytotrophoblasts were isolated fr...
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Human endogenous retroviruses (HERVs) have been shown to be important in physiological and pathophysiological processes in humans. Several HERVs have been found to be expressed in the placenta-a tissue with special immunomodulatory functions that is responsible for nutrition of the embryo and the ability of the semiallogenic trophoblast to invade. The envelope proteins of HERV-W (also known as ...
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BeWo cells derived from a choriocarcinoma have been extensively used as a model of placental trophoblast. There are several clones of the BeWo cell line. Authentication and characterisation of these cloned cell lines is important to ensure their identity and purity prior to use in research. In order to be classified as cytotrophoblasts, cells need to fulfil certain criteria including the expres...
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ژورنال
عنوان ژورنال: Immunology
سال: 2007
ISSN: 0019-2805,1365-2567
DOI: 10.1111/j.1365-2567.2007.02623.x